People will typically start on a lower dose of 2 or 4 mg due to the possible dose-related side effects. A doctor can then increase the dose in increments of 2—4 mg every 1—4 days to achieve the optimal effect possible with a tolerable amount of side effects. People can repeat the dose at 6—8 hour intervals, but they should never exceed three doses, or a total of 36 mg, in 24 hours. It is also worth noting that doctors may use tizanidine with caution in people with liver or kidney impairments, as these issues may decrease the rate of clearance and lead to the drug having a more prolonged effect on the body.
The most common side effects include :. A research article warns against taking tizanidine with fluvoxamine Luvox , a medication for obsessive-compulsive disorder, or ciprofloxacin Cipro , an antibiotic. Either of these combinations may result in low blood pressure or problems with involuntary movements. It is also not advisable to take tizanidine with other CYP1A2 inhibitors, such as birth control pills, due to the possible drug interactions. CYP1A2 is an enzyme that helps metabolize drugs.
If CYP1A2 inhibition occurs, the body will not be able to clear the drug efficiently, which increases the likelihood of adverse reactions. Evidence also suggests that tizanidine may interact with alcohol, other central nervous system depressants, such as opioids, and other central alpha-2 adrenergic agonists. Possible risks associated with tizanidine include :.
Timing and food can make a difference when taking tizanidine. Also, if it becomes necessary to discontinue the drug, the way in which a person does this is important.
Due to the short duration of effect, people should take tizanidine when a reduction in spasticity is most important. If a person accidentally misses a dose, they should skip it if it is almost time for the next dose.
Not allowing 6—8 hours to pass between doses may result in an overdose. The effect of food on tizanidine is complex and can differ depending on whether a person is taking a tablet or capsule. Food can increase some aspects of absorption for tablets but decrease absorption for capsules. Due to this, it may result in a higher likelihood of adverse events or more rapid or delayed effects of the drugs. If someone discontinues tizanidine, they should do so slowly, particularly if they are taking high dosages.
Reducing the dosage gradually can help decrease the risk of withdrawal or other adverse effects, such as high blood pressure or rapid heartbeat.
A doctor will explain the best way to taper off the drug. Pharmacists should dispense the drug in a container with a child-resistant cap.
It is FDA-approved for the management and treatment of various types of spasticity, including those caused by health conditions such as multiple sclerosis, acquired brain injury, or spinal cord injury. Zanaflex also has off-label uses for conditions such as migraine headaches and insomnia. It can also be useful as an anticonvulsant.
With all of these uses, it is important to be completely clear about the required dosage information for the medication before attempting to use it. Over the past few years, Zanaflex has enjoyed a spike in popularity in the healthcare scene. About 1. The number of total prescriptions also rose from 5. As of , this was the 92 most prescribed drug in the country, up from in the year Many people are looking to understand what Zanaflex is, and how it works in their bodies. It is also important to understand how the doses differ based on the treated condition.
The information in this text is best treated for research-purpose only, as advice and a prescription from a qualified doctor should be the only way by which one uses this medication. On that note, the text describes the possible Zanaflex use cases, along with a view on the mechanism of action. It also shows an overview of how long it takes for Tizanidine to work, and related questions are covered for a better understanding of how effective the medicine is. Zanaflex is classified as a type of central alphaadrenergic agonist.
The product is primarily indicated for managing and relieving a clinical symptom known as spasticity. This is why it is mainly classified as a muscle relaxant medication. Patients need to understand how Zanaflex works. The action of this central alphaadrenergic agonist causes pain sensations to be blocked. These are essentially nerve impulses that the body sends to the brain.
Once the brain receives the nerve impulse, it signals the presence of pain sensations. By blocking these sensations, the person would gain temporary relief from the pain that they experience. This is a short-acting muscle relaxant drug. This means its effects can only be experienced for a relatively short period of time once the drug has been administered.
Since multiple doses are needed for longer-term effects to maintain the blocking of pain sensations, using Tizanidine for pain can be tricky, and many ask if it is addictive. By getting more details on the mechanism of action, it is easier to understand what Zanaflex is prescribed for. However, the most important factor to consider here is that even armed with the knowledge of what the drug is used for, one must still be sure to consult a doctor and discuss symptoms with them first before using Zanaflex or any other medication.
Self-medication is extremely dangerous, fatal in some cases, and the only way to make sure that one is receiving the right treatment with the right dosages and prescriptions is to get the information from a qualified healthcare professional. Learn what Zanaflex medicine is used for in this section, by addressing each particular use case separately. One of the most common reasons why Tizanidine for pain is an option is the fact that the medicine is classified as a muscle relaxant.
Tizanidine uses in the treatment of back pain is an ideal choice for individuals who complain about pain in their upper and lower back. Tizanidine for back pain can be effective and assist in blocking pain signals for a certain period of time. The dosage of Tizanidine for back pain will likely be different compared to using the medicine for another purpose, such as Zanaflex for pain in general. Tizanidine 4mg tablets can be used for multiple sclerosis. This is a painful disorder that can cause several unpleasant symptoms.
Similarly, Zanaflex for fibromyalgia is another common way that this medicine helps individuals with chronic diseases. Tizanidine used for the treatment of multiple sclerosis will only bring temporary relief.
This drug is often used for people with multiple sclerosis , spinal cord injury , or muscle spasticity. Tizanidine belongs to a class of drugs called alphaadrenergic agonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Tizanidine reduces the activity of nerves in the spinal cord that control muscles.
This helps to reduce muscle spasms. If these effects are mild, they may go away within a few days or a couple of weeks. Call your doctor right away if you have serious side effects. Serious side effects and their symptoms can include the following:. Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice.
Always discuss possible side effects with a healthcare professional who knows your medical history. Tizanidine oral tablet can interact with other medications, vitamins, or herbs you may be taking.
An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully. Do not take these drugs with tizanidine. When used with tizanidine, these drugs can cause dangerous effects in the body.
Examples of these drugs include:. Taking tizanidine with certain medications raises your risk for side effects from tizanidine. This is because the amount of tizanidine in your body is increased. Avoid using these drugs with tizanidine if possible. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. If you have an allergic reaction, call your doctor or local poison control center right away.
If your symptoms are severe, call or go to the nearest emergency room. Taking it again could be fatal cause death. The use of drinks that contain alcohol increases the amount of tizanidine in your body. This can cause increased side effects from tizanidine. For people with decreased liver function. Talk with your doctor about whether tizanidine is safe for you. If you take this drug, your doctor may give you a lower dose. Also, your doctor should check your liver function at the start of treatment.
They may check it again 1 month after your maximum dose has been prescribed. For people with decreased kidney function. Also, your doctor will watch for buildup of too much tizanidine in your body. Symptoms can include dry mouth, dizziness, or drowsiness.
For pregnant women. Tizanidine is a category C pregnancy drug. That means two things:. This drug should only be used if the potential benefit justifies the potential risk to the fetus. Call your doctor if you become pregnant while taking this drug. For women who are breastfeeding. Talk with your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
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