When was cortisone synthesized

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The first clinical evidence that an extract of animal adrenocortical tissue could counteract human adrenal failure was demonstrated in As chemical analyses of cortical extracts proceeded, mainly in the laboratories of Kendall at the Mayo Clinic and Reichstein in Zurich, it became evident that there is not one cortical hormone, but that all are steroids.

By it was understood that there are two categories: those that cause sodium and fluid retention and those that counteract shock and inflammation. Structurally the presence or lack of oxygenation at C11 on the steroid skeleton was critical. In the first patient with rheumatoid arthritis was treated with cortisone and soon thereafter other rheumatologic patients received cortisone or, to stimulate native cortisone production, ACTH.

Oral and intra-articular administration of cortisone and hydrocortisone began in Several lines of research to produce cortisone semi-synthetically showed some success by